
Ronald Wetzel
This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone (412) 383-5271
Fax (412) 648-8998
University of Pittsburgh
2046 Biomedical Science Tower 3
Ronald Wetzel
Department of Structural Biology
Visit Ron's lab website
Education & Training
Undergraduate
Drexel University, Philadelphia
B.S. 1969 in Chemistry
Postgraduate
Max Planck Institute
Goettingen, German 1973 - 1975
Yale University
New Haven 1975 - 1978
Awards & Honors
1998 Zenith Award, Alzheimer's Association
1999 Lieberman Award, Hereditary Disease Foundation
Representative Publications
Mishra, R., Jayaraman, M., Roland, B.P., Landrum, E., Fullam, T., Kodali, R., Thakur, A.K., Arduini, I., & Wetzel, R., Inhibiting nucleation of amyloid structure in a huntingtin fragment by targeting α-helix rich oligomeric intermediates. J. Mol. Biol. 415: 900-917. 2012.
Jayaraman, M., Mishra, R., Kodali, R., Thakur, A.K., Koharudin, L.M.I., Gronenborn, A.M., & Wetzel, R., Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and properties. Biochem. 51: 2706-2716. 2012.
Mishra, R., Hoop, C.L., Kodali, R., Sahoo, B., van der Wel, P.C.A., & Wetzel, R., Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties. J. Mol. Biol. 424:1-14. 2012.
Kar, K., Hoop, C.L., Drombosky, K.W., Baker, M.A., Kodali, R., Arduini, I., van der Wel, P.C.A., Horne, W.S., & Wetzel, R., -hairpin-mediated nucleation of polyglutamine amyloid formation. J. Mol. Biol., 425: 1183-1197. 2013.
Nafie, L.A., Kurouski, D. , Kar, K., Wetzel, R., Dukor, R.K., and Lednev, I.K., Levels of supramolecular chirality of polyglutamine aggregates revealed by vibrational circular dichroism. FEBS Letts.: 587: 1638-1643. 2013.
Active Grants
Mechanisms of Amyloid Nucleation
04/01/12 – 03/31/17
National Institutes of Health
R01
Structures and Properties of Polyglutamine Proteins and Their Aggregates
06/15/01 – 05/31/16
National Institutes of Health
R01
Training in Molecular Biophysics and Structural Biology
07/01/11 – 06/30/16
National Institutes of Health
T32